Download as PDF, PPTX
Uploaded byKBI Biopharma
KBI Case Studies: Process Development
KBI Case Studies discusses four process development case studies: 1) Improving Titer - KBI routinely improves titer several fold compared to original processes through feed and supplement optimization. 2) Toolbox for Product Quality Optimization - KBI uses strategies around raw materials and process conditions to optimize product quality attributes like galactosylation. 3) High Throughput Process Development Using Microbioreactors - KBI has demonstrated microbioreactor scalability and integrating this technology reduces process development timelines by 1-2 months. 4) High Cell Density Process - KBI has developed high cell density processes exceeding 100 million cells/mL with improved viability and quality profiles using alternating tangential flow technology.
More Related Content
Similar to KBI Case Studies: Process Development
KBI Case Studies: Process Development
- 1. KBI Case Studies ProcessDevelopment Improving Titer Toolbox for Product Quality Optimization High Throughput Process Development Using Microbioreactors High Cell Density Process
- 2. Improving Titer Toolbox forProduct Quality Optimization High Throughput Process Development Using Microbioreactors High Cell Density Process KBI Case Studies Process Development
- 3. KBI Case Studies| Process Development Improving Titer Objective: ● Increase titer compared to the process transferred to KBI Outcome: ● Through feed and supplement optimization, KBI routinely improves titer several fold compared to the process transferred to KBI
- 4. KBI Case Studies| Process Development Improving Titer
- 5. Improving Titer Toolbox forProduct Quality Optimization High Throughput Process Development Using Microbioreactors High Cell Density Process KBI Case Studies Process Development
- 6. KBI Case Studies| Process Development Objective: ● Modify product quality to match a predetermined target through use of a toolbox of strategies around raw materials and process conditions Outcome: ● KBI has a toolbox of strategies to optimize galactosylation, fucosylation, mannonse-5, glycation, and charge distribution Toolbox for Product Quality Optimization
- 7. KBI Case Studies| Process Development Toolbox for Product Quality Optimization
- 8. Improving Titer Toolbox forProduct Quality Optimization High Throughput Process Development Using Microbioreactors High Cell Density Process KBI Case Studies Process Development
- 9. KBI Case Studies| Process Development Objective: ● Demonstrate microbioreactor scalability and shorten process development timeline by using microbioreactors Outcome: ● KBI has demonstrated scalability of ambr microbioreactors and has integrated this technology in process development workflow. Use of microbioreactors can reduce process development timeline by 1 – 2 months. High Throughput Process Development Using Microbioreactors
- 10. KBI Case Studies| Process Development High Throughput Process Development Using Microbioreactors Days Days ViableCellDensity(10^6cells/mL) Viability(%)
- 11. Improving Titer Toolbox forProduct Quality Optimization High Throughput Process Development Using Microbioreactors High Cell Density Process KBI Case Studies Process Development
- 12. KBI Case Studies| Process Development Objective: ● Develop high cell density processes using ATF Outcome: ● KBI has developed high cell density processes (>100 million cells/mL) with improved viability and product quality profiles. High Cell Density Process
- 13. KBI Case Studies| Process Development High Cell Density Process
- 14. www.kbibiopharma.com PO Box 15579 1101Hamlin Road Durham, NC 27704 Tel: +1 919 479 9898 Contact Us